White fat stores of brown fatWhile most people are familiar with white fat, they are probably not too brown, not the store more than fat because it burns. Patrick Seale writes researcher on the role of orexin in its report, "Orexin appears the heat on obesity" burn "brown fat cells produce chemical energy into heat for protection against hypothermia and obesity. See Sellayah et al now that a peptide secreted neuro, orexin, a key factor in brown adipocyte functions through direct actions on brown adipose tissue precursors. "
Researchers have long believed, brown fat, especially burn the fat feed the muscle shoulder blades along the spine and stored on the heart, disappeared after infancy, but recent advances in imaging technology discovered the brown fat in humans. The level of orexin in the body of a person is supposed to be governed by heredity.
Scientists are not aware of other active substances in the body that stimulates brown fat and brain, more orexin. The jury is still out, some scientists believe, on the extent to which orexin plays a significant role. "The idea is to burn excess calories by generating more brown fat still under discussion, says Dr. Carey Lumeng, a researcher of adipose tissue and professor of pediatrics at the University of Michigan in an article for the Orlando Sentinel. " Much has to be elucidated, but my feeling is that it plays a role, but it will not be the only solution, "he said.Orexin active burning brown fat, caloriesBrown fat is loaded with mitochondria and blood vessels, which explains the color, and does a good job of converting calories into energy, a process that does not seem to work well in people who are overweight.
Sanford-Burnham researchers found in their study that orexin-activated calorie burning brown fat in mice. Obesity can be produced in some people, a deficiency in brown adipose tissue thermogenesis, heat is generated as a process and an integral part of weight regulation.The researchers studied mice that are more than their normal counterparts but actually weighed less food consumed, suggesting that overeating is not the cause of their obesity, that something was happening. Obese mice, it turns out, were orexin deficiency reduces thermogenesis (heat production). If obese mice fed a high fat diet their bodies have not been getting rid of extra calories as heat, how-size mouse is, obese mice (and humans) lack orexin stored energy as fat.
Researchers believe that mice lacking orexin not develop properly in the embryo, which, as its body weight and energy consumption has increased, but it takes an adult. "Our study provides a possible reason why some people are overweight or obese, despite the fact they do not eat too much, orexin may need to activate brown fat and consumption of energy can increase be absent, "said Devanjan Sikder, DVM, PhD. D., Author of the study and assistant professor at Sanford-Burnham Diabetes and Obesity Research Center,
Orexin and control type 2 diabetes, cardiovascular disease and certain cancersBecause the lack of orexin is linked to obesity, the results can be seen orexin supplement offer a new therapeutic approach for treating obesity and other metabolic disorders. Approximately one third of American adults (33.8 percent) are obese, according to the Centers for Disease Control and Prevention, she has placed an increased risk of type 2 diabetes, coronary heart disease, stroke and certain cancers.While most weight loss drugs to a person who works to suppress appetite, is an approach based on the orexin to focus on peripheral tissues rather than central fat burning appetite control brain.
"Controlling obesity by controlling hunger does not work because the body has ways of compensating," says Dr. Devanjan Skiler, lead author of the study by the Institute. "Orexin uncontrolled hunger uses excess calories. Agent is different than others because it lets you down and eat to lose burn the fat feed the muscle
